Soledad O'Brien anchors American Morning with Miles O'Brien. Based in New York, O'Brien began anchoring CNN's flagship morning program in July 2003 when she joined the network. Since that time, O'Brien has attracted new viewers to the show as well as securing exclusive interviews.

For CNN's Hurricane Katrina coverage, O'Brien conducted daily reports about the impact of Hurricane Katrina including an in-depth interview with former FEMA chief Michael Brown. She also covered the London terrorism attacks in July 2005, and in December 2004, she was among a handful of CNN anchors sent to Puhket, Thailand, to cover the disaster and aftermath of the tsunami that took more than 155,000 lives. She reported from Columbus, Ohio, on the late count of Ohio's contested electoral votes in November 2004. Earlier that fall, she anchored the live coverage of the burial of Yasser Arafat. In the fall of 2003, O'Brien was the only broadcast journalist permitted to travel with first lady Laura Bush on her trip to Moscow.

O'Brien came to CNN from NBC News where she had anchored the network's Weekend Today since July 1999. During that time, she contributed reports for the weekday Today Show and weekend editions of NBC Nightly News and covered such notable stories as John F. Kennedy Jr.'s plane crash and the school shootings in Colorado and Oregon. In 2003, she covered the Space Shuttle Columbia disaster and later anchored NBC's weekend coverage of the war in Iraq. Additionally, in 1998, she traveled to Cuba to cover Pope John Paul II's historic visit.

Before Weekend Today, O'Brien anchored MSNBC's award-winning technology program The Site and the cable network's weekend morning show. O'Brien joined NBC News in 1991 and was based in New York as a field producer for Nightly News and Today. Before her time at NBC, she served three years as a local reporter and bureau chief for the NBC affiliate KRON in San Francisco. She began her career as an associate producer and news writer at the then-NBC affiliate, WBZ-TV in Boston.

O'Brien was part of the coverage teams that earned CNN a George Foster Peabody award for its Katrina coverage and an Alfred I. duPont Award for its coverage of the tsunami disaster in Southeast Asia. In 2006, she was awarded the Women of Power award by the National Urban League. From the National Association of Minorities in Cable she received the Mickey Leland Humanitarian award for 2006 as well as the Excellence in English Language Media by HOLA -the Hispanic Organizational of Latin Actors. She also won a local Emmy for her work as a co-host on Discovery Channel's The Know Zone. She has been named to PEOPLE magazine's "50 Most Beautiful" in 2001 and PEOPLE en Espanol's 50 most beautiful in 2004. O'Brien was also included in Crain's Business Reports' "40 under 40's", Essence magazine's "40 under 40's" and Black Enterprise "40 Under 40's". O'Brien has been named several times to Irish American Magazine's "Top 100 Irish Americans". O'Brien was recognized by the National Association of Minorities in Cable Vision Award in 2006 and has received honorary degrees from Siena College and Mercy College.

She is a member of the National Association of Black Journalists and the National Association of Hispanic Journalists. O'Brien is a graduate of Harvard University with a degree in English and American literature.